Comments for TotallyMechanistic

Comment on Sodium borohydride/iodine reduction by Roger

Roger — Wed, 16 Sep 2009 02:00:13 +0000

You would react the alcohol with thionyl chloride (SOCl2), or PBr3 to create the alkyl halide (R-X). The X (Halogen; Cl or Br)is then replaced using any number of hydrogenation methods (LAH, H2& Ni, H2 & Pb).

My question is simple; Has anyone any information on any CNS effects of the compound given above as an example (the reduction product of phenylalanine – referred to as phenylalinol, or alpha-methoxy phenylethylamine?)

Comment on Sodium borohydride/iodine reduction by Peter Piper

Peter Piper — Wed, 01 Jul 2009 04:29:22 +0000

But how does one reduce an amino alcohol, to an amine?
Any refs would be great!

Comment on Sodium borohydride/iodine reduction by tulasi

tulasi — Sun, 17 May 2009 17:35:06 +0000

Dear sir,
I tried reduction 0f Phenyl alanine with NaBH4(1.0 eq) in THF and H2So4(1.25eq) in ether,but i didnt get the product,and also i t is difficult to check tlc after fomation of BH3 comlex.

Comment on Sodium borohydride/iodine reduction by Sachin M.S; Ph.D

Sachin M.S; Ph.D — Wed, 01 Apr 2009 09:30:57 +0000

The THF traces in the reaction mixture can be easily removed by taking product in organic solvent and giving it a water wash. The organics is then dried over anhydrous sodium sulphate and evaporated, dried further over vaccum for about half an hour under warm heating. This is rally a good way of doing this reaction…one naother option is use BH3/DCM as an alternate of BH3/THF(dry).
Thanks & Regards,

Comment on Neotripterifordin by Corey/Liu by gra

gra — Tue, 23 Sep 2008 18:28:37 +0000

Iodine activates the triphenyl phosphine making iodide I- and triphenylphosphonium iodide Ph3PI+, then the alcohol reacts with the triphenylphosphonium salt to make an intermediate R-OH-P+R3, which readily deprotonated by imidazole, iodide ion displaces triphenyl phosphine oxide from the deprotonated intermediate and generates RI.

Comment on And so it all began… by sasha

sasha — Mon, 05 May 2008 20:58:00 +0000

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Comment on Neotripterifordin by Corey/Liu by pmgb

pmgb — Tue, 22 Apr 2008 22:41:39 +0000

Check out the supp info of Toste, Radosevich, Chan and Shih, ACIEE, 2008, EarlyView. DOI: 10.1002/anie.200800554 for a impressive list of procedures..

Comment on Sodium borohydride/iodine reduction by pmgb

pmgb — Tue, 22 Apr 2008 05:12:36 +0000

I did the same like java-reduction of ethyl esters to alcohols using NaBH4 alone (in ethanol)…

Comment on Neotripterifordin by Corey/Liu by pmgb

pmgb — Tue, 22 Apr 2008 01:50:11 +0000

For procedures, I generally visit alsnotebook.com.

Comment on And so it all began… by feechka-ha

feechka-ha — Thu, 21 Feb 2008 11:22:59 +0000

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